Paracetamol Production from p-Nitrophenol
Paracetamol Production Costs Report | Issue D | Q3 2024
| Report Details |
| 20 kta United States-based plant | Q3 2024 | 107 pages |
This report presents a cost analysis of a 20 kta (kilo metric ton per annum) United States-based plant. You can add a customized cost analysis, assuming another location (country), when ordering a premium edition of this report.
Report Abstract
This report analyses the economics of Paracetamol production from p-nitrophenol (PNP) and acetic anhydride. The PNP is then subjected to reduction, producing p-aminophenol (PAP). The PAP is then acetylated to produce Paracetamol. The economic analysis is based on a plant located in the United States.
The report provides a comprehensive study of Paracetamol production and related Paracetamol production cost, covering three key aspects: a complete description of the Paracetamol production process examined; an in-depth analysis of the related Paracetamol plant capital cost (Capex); and an evaluation of the respective Paracetamol plant operating costs (Opex).
The Paracetamol production process description includes a block flow diagram (BFD), an overview of the industrial site installations, detailing both the process unit and the necessary infrastructure, process consumption figures and comprehensive process flow diagrams (PFD). The Paracetamol plant capital cost analysis breaks down the Capex by plant cost (i.e., ISBL, OSBL and Contingency); owner's cost; working capital; and costs incurred during industrial plant commissioning and start-up. The Paracetamol plant operating costs analysis covers operating expenses, including variable costs like raw materials and utilities, and fixed costs such as maintenance, labor, and depreciation.
Process Overview
Product
Paracetamol. Paracetamol (a.k.a. Acetaminophen, APAP, 4-Hydroxyacetanilide, 4-Acetoamidophenol) is a synthetic derivative of p-aminophenol, and has analgesic and antipyretic properties. Harmless at low doses, it has direct hepatotoxic potential when taken as an overdose and can cause acute liver injury and death from acute liver failure.
Raw Materials
Acetic Anhydride. Acetic Anhydride (a.k.a. Ethanoic Anhydride, Acetyl Oxide, Acetic Oxide) is a colorless liquid with an odor that resembles acetic acid. Figuring among the most produced carboxylic acid anhydrides, Acetic Anhydride is a major organic intermediate with an important role in many chemical reactions, like acetylations, production of other acid anhydrides, hydrolysis to produce acetic acid and many others. It is widely used as a solvent for chemical analyses as well.
p-Nitrophenol. p-Nitrophenol is an aromatic compound used as a precursor in the synthesis of dyes, pharmaceuticals, and pesticides. Its strong electrophilic properties make it a key reagent in various chemical reactions. p-Nitrophenol is produced via the nitration of phenol and is stored as a pale yellow crystalline solid. Its ability to act as an indicator in biochemical assays due to its pH sensitivity further expands its use in research and industrial applications.
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Production Process Information
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Production Process Information
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Production Process Information
Process Consumptions
Labor Requirements
Plant Capital Cost Summary
Operating Cost Summary
Production Costs Datasheet
Plant Capital Cost Details
Operating Cost Details
Plant Cost Breakdowns
Plant Capacity Assessment
Process Flow Diagrams
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Content Highlights
Plant Capital Cost Summary
Summary outlining the capital cost required for building the Paracetamol production plant examined
Plant Capital Cost Details
Detailing of fixed capital (ISBL, OSBL & Owner’s Cost), working capital and additional capital requirements
Plant Cost Breakdowns
Breakdown of Paracetamol process unit (ISBL) costs and infrastructure (OSBL) costs; plant cost breakdown per discipline
Operating Costs Summary
Summary presenting the operating variable costs and the total operating cost of the Paracetamol production plant studied
Operating Cost Details
Detailing of utilities costs, operating fixed costs and depreciation
Plant Capacity Assessment
Comparative analysis of capital investment and operating costs for different Paracetamol plant capacities
Production Process Information
Block Flow Diagram, descriptions of process unit (ISBL) and site infrastructure (OSBL)
Process Consumptions
Raw materials and utilities consumption figures, by-products credits, labor requirements
Process Diagrams
Process flow diagrams (PFD), equipment list and industrial site configuration
Other Paracetamol Production Cost Reports
Paracetamol Production from p-Nitrochlorobenzene
This report analyses the economics of Paracetamol production from 4-nitrochlorobenzene and acetic anhydride in the United States. In the process, 4-nitrochlorobenzene reacts with sodium hydroxide producing para nitro phenol (PNP). The PNP is then subjected to reduction, producing para amino phenol (PAP). The PAP is then acetylated to produce Paracetamol.
Details: 20 kta United States-based plant | Q3 2024 | 107 pages | Issue A From $1,999 USD
The cost analyses presented in this report target a 20 kta (kilo metric ton per annum per annum) United States-based plant. For those interested in cost analyses considering other plant capacities and/or locations, Intratec offers a customized analysis as an optional feature.
Paracetamol Production from Nitrobenzene
This report approaches the production of Paracetamol from nitrobenzene and acetic anhydride in the United States. In this process, nitrobenzene is contacted with hydrogen in the presence of dilute sulfuric acid, generating 4-aminophenol (PAP) and aniline by-product. The PAP is then acetylated to produce Paracetamol.
Details: 20 kta United States-based plant | Q3 2024 | 107 pages | Issue B From $1,999 USD
The cost analyses presented in this report target a 20 kta (kilo metric ton per annum per annum) United States-based plant. For those interested in cost analyses considering other plant capacities and/or locations, Intratec offers a customized analysis as an optional feature.
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Other Related Production Cost Reports
Acetic Anhydride Production from Acetic Acid and Acetone
This feasibility study reviews the Acetic Anhydride production from acetone and acetic acid. Initially, acetone is converted to ketene via pyrolysis. Then, the ketene is absorbed in acetic acid to produce acetic anhydride. The economic analysis presented assumes a plant located in the United States.
Details: 120 kta United States-based plant | Q3 2024 | 107 pages | Issue B From $1,199 USD
The cost analyses presented in this report target a 120 kta (kilo metric ton per annum per annum) United States-based plant. For those interested in cost analyses considering other plant capacities and/or locations, Intratec offers a customized analysis as an optional feature.
p-Nitrophenol Production
This report analyses the economics of p-Nitrophenol (PNP) production from 4-nitrochlorobenzene and sodium hydroxide. In the process, 4-nitrochlorobenzene reacts with sodium hydroxide producing PNP, which is then concentrated and treated to be obtained as a pure product. The economic analysis is based on a plant located in the United States.
Details: 4.80 kta United States-based plant | Q3 2024 | 107 pages | Issue A From $999 USD
The cost analyses presented in this report target a 4.80 kta (kilo metric ton per annum per annum) United States-based plant. For those interested in cost analyses considering other plant capacities and/or locations, Intratec offers a customized analysis as an optional feature.
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